2 edition of Absorption of short chain fatty acids from the human rectum and distal colon. found in the catalog.
Absorption of short chain fatty acids from the human rectum and distal colon.
Janet Anne Vogt
Thesis (M.Sc.) -- University of Toronto, 1995.
|Series||Canadian theses = -- Thèses canadiennes|
|The Physical Object|
|Pagination||2 microfiches : negative. --|
Mode1 for cellular mechanism involved in absorption of short chain fatty acids in the proximal and distal colon of guinea pig. Mean*SEM serum calcium increments of six healthy men after 80 rectal infusion of solutions containing sodium chloride or 30 mmoles calcium chloride with and without short chain fatty Many species of bacteria exist in the fish digestive tract (Horsley , Rimmer and Wiebe , Ringø and Birkbeck and the existence of short-chain fatty acids (SCFA) such as acetic
The effect of short-chain fatty acids (SCFAs) on the contractile activity and fluid output of the large bowel of the rat was studied using an isolated segment of cecum and colon, mounted in :// 1. Introduction. The colon can maintain the health of the whole body by absorbing water and electrolytes, and salvaging unabsorbed nutrients .It has been shown that short chain fatty acid (SCFA) and pH values play crucial roles in intestinal tract health [2,3,4].SCFA are metabolic by-products of the gut microbiota fermentation in the colon .
Roediger WE, Moore A. Effect of short-chaim fatty acid on sodium absorption in isolated human colon perfused through the vascular bed. Dig Dis Sci. Feb; 26 (2)– Binder HJ, Mehta P. Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology. Apr; 96 (4)– 1. Effects of H+ secreting mechanisms on unidirectional passage of the short‐chain fatty acids (SCFA) acetate, propionate and n‐butyrate across isolated guinea‐pig caecum, proximal and distal colon were studied under short‐circuit current conditions in Ussing chamber isotope flux ://
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Gastroenterology ; 7) McNeil NI, Cummings JH, James WPT. Short-chain fatty acid absorption by the human large intestine. Gut ; 8) Hassan MA, Hobsky M. Positioning of subject and nasogastric tube during a gastric secretion study.
Br Med J ; 9) Cummings JH. Short-chain fatty acids in the human :// Short-chain fatty acids (SCF As) constitute the major solute fraction of normal stool water and are respon sible for the diarrhea associated with carbohydrate (CHO) malabsorption.
Although SCFA absorption from the human small bowel has been reported pre viously, the fate of SCF As in the colon-their major site of production-was investigated (19)/pdf.
Absorption of short-chain fatty acids by the colon. Gastroenterology, Sakata, T., Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in the rat intestine: a possible explanation for trophic effects of fermentable fibre, gut microbes and luminal trophic factors.
Nutr., Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides coupled with lower levels and slower absorption, may be important in human distal ulcerative colitis where it has been hypothesized that there is a defect in butyrate metabolism.
The distal large colon and rectum are the regions Short chain fatty acids (SCFAs) have been the subject of much research over the past few decades.
the exact aetiology is unclear. 9 SCFAs also increase blood flow in the dog colon and the human rectum, 10, The authors concluded that dietary fibre associated with increased butyrate concentration in the distal colon is protective against Presented in part at Experimental Biol April,Washington, D.C.
[Vogt, J. & Wolever, T.M.S. () Absorption of short chain fatty acids from the human rectum and distal colon. FASEB J. 9(3): A] and the Canadian Federation of Biological Sciences, June,London, Canada [Vogt, J.
& Wolever, T.M.S. () Absorption of Short Short-Chain Fatty Acids. Short-chain fatty acids (SCFAs) are potent stimuli of sodium and water absorption in the colon, – with butyrate being the most effective. It has been speculated that the SCFA-mediated increase in Na + absorption is due to the coupling of two exchange mechanisms, Na + /H + and SCFA − /Cl Short chain fatty acids (SCFA) mainly acetic, propionic and Send Correspondence and reprlnt requests to Dr.
Lilian U. Thompson T.P. TRINIDAD et al. butyric acids, which are the major products of the fermentation of dietary fibers have been suggested to enhance the absorption of calcium (Ca) and magnesium in the rat colon (5,11,13).
Abstract. Short chain fatty acids (SCFAs) are the end products of anaerobic bacteria break down of carbohydrates in the large bowel. This process, namely fermentation, is an important function of the large bowel; SCFAs, mainly acetate, propionate and butyrate account for approximately 80% of the colonic anion concentration and are produced in nearly constant molar ratio Binder HJ, Mehta P.
Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology. Apr; 96 (4)– [Google Scholar] Scheppach W, Sachs M, Bartram P, Kasper H.
Faecal short-chain fatty acids after colonic surgery. Eur J Vogt, J. & Wolever, T. Fecal Acetate Is Inversely Related to Acetate Absorption from the Human Rectum and Distal Colon.
The Journal of Nutrition– (). From a solution with mixed short chain fatty acids acetate concentration fell from to mmol/l, propionate from to mmol/l, and butyrate from to mmol/l with absorption Absorption of short-chain fatty acids (SCFA), acetate, propionate, and butyrate was studied in simultaneously perfused proximal and distal segments of the colon in anaesthetized guinea pigs.
Acetate absorption rates increased linearly with concentration in Rübsamen K, Engelhardt W v () Absorption of Na, H ions and short-chain fatty acids from the sheep colon. Pflügers Arch – PubMed CrossRef Google Scholar Ruppin H, Bar-Meir S, Soergel KH, Wood CM, Schmitt MG Jr () Absorption of short-chain fatty acids by the :// Ulcerative colitis (UC) and Crohn's disease (CD), collectively known as Inflammatory Bowel Diseases (IBD), are caused by a complex interplay between genetic, immunologic, microbial and environmental factors.
Dysbiosis of the gut microbiome is increasingly considered to be causatively related to IBD and is strongly affected by components of a Western life :// Short-chain fatty acids are readily absorbed from the lumen and are used as metabolic precursors; acetate is utilized for lipogenesis in the liver and as a fuel source once it enters the peripheral circulation.
Propionate is largely taken up by the liver, and is used as a substrate for hepatic :// Abstract. Short chain fatty acids (SCFAs) are potentially valuable as a topical therapy for distal ulcerative colitis.
The mechanism of action is unknown but may involve improved intracellular energy production as previous evidence indicates that colonocyte oxidation of butyrate is impaired in ulcerative :// bon short-chain fatty acids, account for X)%% of the short-chain fatty acids in the colon, with isobu- tyrate, valerate, isovalerate, and caproate account- ing for the rest.7 Within the colon contents, the short-chain fatty acids account for most of the anions ( (92)O/pdf.
Absorption of SCFA from the colon is very efficient with less than 5% being excreted in faeces. Short-chain fatty acids and human colonic function:roles of resistant starch and nonstarch A method of perfusing the isolated human colonin vitro was developed to study the effect of the short-chain fatty acidn-butyrate on sodium absorption under controlled conditions.
The isolated colon was viablein vitro provided that ischemia to the colon prior to perfusion was less than 40 min. Viability was judged on glucose utilization, mucosal potential difference, and sodium ://. Short Chain Fatty Acid Distal Colon Absorption of short chain fatty acids from the large intestine, in Physiological and Clinical Aspects of Short-Chain Fatty Acids (eds.
Cummings, ferentiation of the human colon cell line HT International Journal of Cancer 52 –Rechkemmer G and Engelhardt W von. Concentrations and pH dependence of short chain fatty acids absorption in the proxinal and distal colon of guinea pigs (Cavia procellus).
Comp Biochem Physiol ; 91A– CrossRef Google ScholarShort-chain fatty acids such as acetic, propionic, and n-butyric acids are produced from carbohydrates by microbes in the forestom - ach and/or in the cecum or colon (Macfarlane & Macfarlane, ; Wallace, ). Short-chain fatty acids (SCFAs) are important energy nutrient for many species such as ruminants, camelids, or marsupials